Home Infertility Treatement

Paternal Lymphocyte Immunization (PLI)

🧬 Paternal Lymphocyte Immunization (PLI)

Paternal Lymphocyte Immunization (PLI) is an advanced immunotherapy used to enhance the mother’s immune response for successful conception and pregnancy maintenance. At Phular IVF Hospital, Muzaffarpur, this specialized procedure helps couples with repeated IVF failures or recurrent miscarriages due to immune-related issues.

💡 What is PLI?

PLI is a form of immunotherapy where lymphocytes (a type of white blood cell) from the male partner are injected into the female partner to help her immune system recognize and accept the partner’s genetic material. This helps create a more favorable immune environment for embryo implantation and reduces the risk of immune rejection that may lead to miscarriage.

🔬 Why is PLI Needed?

When a woman’s immune system mistakenly identifies the embryo as “foreign” and attacks it.
For couples with unexplained infertility despite normal test results.
In cases of repeated IVF implantation failure.
For women experiencing recurrent pregnancy loss due to immune incompatibility.
To improve maternal immune tolerance toward paternal antigens.

⚙️ How is the PLI Procedure Done?

Blood Collection: A small amount of blood is taken from the male partner.
Processing: The laboratory isolates lymphocytes (immune cells) from the blood.
Immunization: These purified lymphocytes are injected intradermally (under the skin) into the female partner’s forearm.
Follow-Up Sessions: The process may be repeated every few weeks as recommended by the fertility specialist.

🧫 How Does PLI Work?

Normally, during pregnancy, the mother’s immune system develops tolerance toward the father’s genetic contribution in the embryo. In some cases, this tolerance fails, leading to pregnancy loss. PLI helps the mother’s immune system recognize paternal antigens in advance, producing “blocking antibodies” that protect the embryo from immune rejection — allowing for better implantation and pregnancy continuity.

🎯 Benefits of Paternal Lymphocyte Immunization

Improves implantation success rates in IVF cycles.
Reduces the risk of recurrent miscarriage.
Enhances immune tolerance toward paternal antigens.
Boosts the chances of natural conception in some couples.
Provides a safe, non-hormonal fertility support method.

⚠️ Safety and Considerations

PLI is a safe, well-tolerated outpatient procedure when performed by qualified fertility experts. At Phular IVF Hospital, we follow strict medical and ethical guidelines to ensure the safety and compatibility of both partners. Screening tests are performed before PLI to rule out infections or blood-borne diseases.

🏥 PLI at Phular IVF Hospital, Muzaffarpur

At Phular IVF Hospital, our team of fertility specialists performs Paternal Lymphocyte Immunization using advanced laboratory techniques in a sterile, controlled environment. We focus on personalized immunotherapy plans based on each couple’s medical history and immunological test results to maximize pregnancy success.

Book PLI Consultation