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PGT-A (Preimplantation Genetic Testing for Aneuploidy)

🧬 Preimplantation Genetic Testing for Aneuploidy (PGT-A)

PGT-A (Preimplantation Genetic Testing for Aneuploidy) is an advanced genetic screening procedure performed on embryos created through IVF. It helps identify embryos with the correct number of chromosomes — improving implantation success, reducing miscarriage risk, and increasing the chances of a healthy pregnancy. At Phular IVF Hospital, Muzaffarpur, we use the latest Next-Generation Sequencing (NGS) technology for highly accurate results.

PGT-A Genetic Testing

💡 What is PGT-A?

PGT-A is a genetic test that examines embryos for abnormal chromosome numbers (known as aneuploidy). Embryos with too many or too few chromosomes often fail to implant or cause early miscarriage. By testing embryos before transfer, fertility specialists can select the healthiest ones for transfer — improving pregnancy rates and ensuring genetic normalcy.

🔬 Why is PGT-A Recommended?

  • For women aged 35 years or older with higher chances of chromosomal abnormalities.
  • Couples with a history of recurrent miscarriage.
  • Those who have had repeated IVF implantation failures.
  • Couples carrying chromosomal translocations.
  • For patients wishing to reduce the risk of genetic abnormalities in their baby.

⚙️ How is PGT-A Performed?

  1. 1. IVF & Embryo Creation: Eggs are fertilized with sperm in the lab to create embryos.
  2. 2. Embryo Biopsy: On day 5 (blastocyst stage), a few cells are carefully removed from the embryo’s outer layer (trophectoderm).
  3. 3. Genetic Analysis: The cells are tested using Next-Generation Sequencing (NGS) to detect chromosomal abnormalities.
  4. 4. Embryo Freezing: The tested embryos are frozen while awaiting results.
  5. 5. Embryo Transfer: Only chromosomally normal (euploid) embryos are selected and transferred into the uterus.

📊 What Does PGT-A Detect?

  • Aneuploidy: Extra or missing chromosomes (e.g., Down syndrome – Trisomy 21).
  • Mosaicism: Presence of both normal and abnormal cells in one embryo.
  • Sex Chromosome Disorders: Abnormalities in X or Y chromosomes.

🎯 Benefits of PGT-A

  • Higher success rate per embryo transfer.
  • Reduced risk of miscarriage.
  • Better embryo selection for healthy pregnancy.
  • Shorter time to pregnancy and fewer IVF cycles needed.
  • Decreased risk of genetic disorders in the baby.

⚠️ Considerations

While PGT-A greatly improves IVF outcomes, it does not guarantee pregnancy or completely eliminate all genetic risks. The procedure requires highly skilled embryologists and state-of-the-art laboratory facilities — both available at Phular IVF Hospital.

🏥 PGT-A at Phular IVF Hospital, Muzaffarpur

At Phular IVF Hospital, our embryology and genetic testing labs are equipped with cutting-edge technology for embryo biopsy and Next-Generation Sequencing (NGS) analysis. Our team works closely with certified genetic specialists to ensure accurate results and ethical embryo selection. We aim to help every couple achieve a healthy, successful pregnancy with confidence.

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